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KMID : 0371019760090010087
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Journal of Preventive Medicine and Public Health
1976 Volume.9 No. 1 p.87 ~ p.94
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Effect of oral D-penicillamine in Urinary excretion of lead
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Park Chung-Yill
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Abstract
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In order to study the chelating action of d-penicillamine on lead and the possibility of its application to the provocation test for diagnosis of lead poisoning, urinary excretion of lead was measured from 24-hour urine samples before, during and after administration of d-penicillamine by oral route for 5 days on 18 lead workers.
The results were as follows:
1. Oral d-penicillamine 600 mg/day raised the excretion of urinary lead by approximately 3 times as compared with initial urinary lead level.
2. Initial urinary lead level was the better indicator of urinary lead excretion in d-penicillamine administration than initial blood lead 8-ALA and hemoglobin level.
3. Oral d-penicillamine may be quite useful in provocation test for lead poisoning.
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